Infections with strains of Staphylococcus sciuri are a potential threat to animal and public health, and a cause for considerable concern. S. sciuri as one of the real pathogen from an acute case of EE in piglets was isolated and has been first identified in genus. Clinical cases of lesions of lungs and endocarditis in piglets due to S. sciuri was first reported. Methicillin-resistant staphylococci must be really careful in public and animal health. Non-toxigenic S. sciuri is fatal to mice and newly bom piglets the reason for sudden death which may be septic shock.