Gene expression profiling to identify the toxicities and potentially relevant human disease outcomes associated with environmental heavy metal exposure

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• 作者：Hesham M. Korashy^a ; ^{hkorashy@ksu.edu.sa} ; Ibraheem M. Attafi^a ; Konrad S. Famulski^b ; Saleh A. Bakheet^a ; Mohammed M. Hafez^a ; Abdulaziz M.S. Alsaad^a ; Abdul Rahman M. Al-Ghadeer^c
• 关键词：Heavy metals ; Mining activity ; Mercury ; Lead ; Microarray ; Renal diseases
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：221
• 期：Complete
• 页码：64-74
• 全文大小：1264 K
• 卷排序：221

文摘

A total of 2129 genes were differentially expressed by exposure to Pb, Cd, and Hg. Approximately 425 altered genes were common in heavy metal-exposed subjects. Among the 425 shared genes, 382 were upregulated, whereas 43 were downregulated. Chronic kidney diseases are the most significant and enriched renal diseases affected. IPA analysis identified the activation of two significant upstream regulators, MYCN and MYC.