Bacterial Biofilms in Colorectal Cancer Initiation and Progression

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• 作者：Shan Li¹ ; Sergey R. Konstantinov¹ ; Ron Smits¹ ; Maikel P. Peppelenbosch¹ ; ^{m.peppelenbosch@erasmusmc.nl}
• 关键词：biofilm ; colorectal cancer ; microbiome ; tumor initiation ; progression.
• 刊名：Trends in Molecular Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：18-30
• 全文大小：2628 K
• 卷排序：23

文摘

Intestinal microbiota have emerged as an important factor in colorectal cancer (CRC) initiation and progression. The currently prominent view on bacterial tumorigenesis is that CRC initiation is triggered by local mucosal colonization with specific pathogens (drivers), and that subsequent changes in the peritumoral environment allow colonization by opportunistic (passenger) microbes, further facilitating disease progression. Screening for CRC ‘driver-passenger’ microorganisms might thus allow early CRC diagnosis or preventive intervention. Such efforts are now being revolutionized by the notion that CRC initiation and progression require organization of bacterial communities into higher-order structures termed biofilms. We explore here the concept that a polymicrobial biofilm promotes pro-carcinogenic activities that may partially underlie progression along the adenoma–CRC axis.