Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity
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- 作者：Ekaterina A. Alyamkina ; Evgenia V. Dolgova ; Anastasia S. Likhacheva ; Vladimir A. Rogachev ; Tamara E. Sebeleva ; Valeriy P. Nikolin ; Nelly A. Popova ; Elena V. Kiseleva ; Konstantin E. Orishchenko ; Ludmil
- 关键词：Nucleosome-free fragmented dsDNA ; Mononuclear cells ; Lung tuberculosis ; Allostimulatory activity
- 刊名：Cellular Immunology
- 出版年：2010
- 出版时间：2010
- 年：2010
- 卷：262
- 期：2
- 页码：120-126
- 全文大小：491 K
文摘
Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli.