Cytotoxicity evaluation of large cyanobacterial strain set using selected human and murine in vitro cell models
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- 作者：Pavel Hrouzeka ; hrouzekp@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aleksandra Kapuścika ; Jan Vacekb ; Kateřina Vorá ; čová ; a ; c ; Jindři&scaron ; ka Paichlová ; a ; Pavel Kosinab ; Ludmila Voloshkod ; Stefano Venturae ; Jiří ; Kopecký ; a
- 关键词：Cytotoxicity ; Cyanobacteria ; Cell lines ; Primary cultures ; Hepatocytes ; MTT test
- 刊名：Ecotoxicology and Environmental Safety
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：177-185
- 全文大小：1437 K
文摘
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The cytotoxic properties of a large cyanobacterial strain set (n>100) are described.
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One third of the cyanobacterial extracts exhibited cytotoxic activities.
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A comparison of human and rodent cell models using the MTT method is reported.
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It was shown that the analysis of one cyanobacterial toxin (toxicity marker) is not sufficient.
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A broad spectrum of compounds participates in the resulting cytotoxicity.