Overexpression of GRß in colonic mucosal cell line partly reflects altered gene expression in colonic mucosa of patients with inflammatory bowel disease
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- 作者：Zsolt Nagya ; b ; Bence Acsa ; Henriett Butzb ; c ; Karolina Feldmana ; Alexa Martaa ; Peter M. Szaboc ; Kornelia Baghyd ; Tamas Pazmanye ; Karoly Racza ; c ; Istvan Likob ; e ; Attila Patocsb ; f ; patocs.attila@med.semmelweis-univ.hu" class="auth_mail" title="E-mail the corresponding author ; patatt@bel2.sote.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucocorticoid receptor beta ; Glucocorticoid resistance ; Inflammation ; Inflammatory bowel disease ; Gene expression
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：155
- 期：part_PA
- 页码：76-84
- 全文大小：2035 K
文摘
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GRß overexpression rendered Caco-2 cells steroid insensitive.
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GRß was located in the nucleus and had an GRα independent transcriptional activity.
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GRß regulated the expression of numerous involved in intact barrier function.