A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis
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- 作者：Youtao Liu1 ; 5 ; Jesus Lacal2 ; 5 ; Douwe M. Veltman3 ; Fabrizia Fusetti4 ; Peter J.M. van Haastert1 ; Richard A. Firtel2 ; 6 ; Arjan Kortholt1 ; 6 ; a.kortholt@rug.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：6 June 2016
- 年：2016
- 卷：37
- 期：5
- 页码：458-472
- 全文大小：4221 K
文摘
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The Rap1GEF GlfB is a receptor-proximal regulator of chemotaxis in Dictyostelium
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GflB localizes to the leading edge and is stimulated directly by Gα-GTP binding
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GflB directly links Gα activation to monomeric G-protein signaling
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GflB provides a mechanism to discriminate between distinct chemoattractants