- 作者：Tuomas O. Kiviniemi ; Antti Saraste ; Terho Lehtimä ; ki ; Jyri O. Toikka ; Markku Saraste ; Olli T. Raitakari ; Jaakko J. Hartiala ; Jorma Viikari ; Juha W. Koskenvuo
- 关键词：Coronary artery diameter ; Endothelin-1 ; Red wine ; De-alcoholized red wine
- 刊名：Atherosclerosis
- 出版年：2010
- 出版时间：July 2010
- 年：2010
- 卷：211
- 期：1
- 页码：283-286
- 全文大小：131 K
BackgroundRed wine consumption may influence on vasoconstrictive peptide endothelin-1 levels, and this may be one mechanism leading to improved vasodilation after red wine consumption. Endothelin-1 levels and their association with coronary epicardial diameter and flow rate, however, have not been studied in vivo after consumption of red wine and de-alcoholized red wine. The purpose of this randomized trial was to determine the acute effects of these beverages on endothelin-1 levels and compare them to coronary artery epicardial diameter and flow rate.Methods
Twenty-two healthy men consumed a high dose (8.1 ± 0.9 dL) of alcohol-containing red wine and de-alcoholized red wine in a cross-over design at one sitting with a two-week washout period. Endothelin-1 levels were determined and coronary artery diameter and flow rate assessed using transthoracic echocardiography before and acutely after intervention.
Results
Red wine and de-alcoholized red wine significantly decreased endothelin-1 levels (0.75 ± 0.26 pg/mL to 0.61 ± 0.20 pg/mL, p = 0.002; 0.74 ± 0.32 pg/mL to 0.63 ± 0.24 pg/mL, p = 0.04, respectively), but did not have a significant effect on epicardial diameter (1.1 ± 0.3 mm vs. 1.1 ± 0.3 mm, p = 0.58; and 1.1 ± 0.3 mm vs. 1.1 ± 0.2 mm, p = 0.10, respectively) or flow rate (7.8 ± 4.0 mL/min to 6.4 ± 3.6 mL/min, p = 0.07; and 7.8 ± 4.0 mL/min to 7.4 ± 3.2 mL/min, p = 0.53, respectively).
Conclusions
Red wine and de-alcoholized red wine decreased plasma endothelin-1 levels after acute consumption, but this change was not reflected in coronary epicardial diameters or flow rate.