Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis

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• 作者：Kotaro Sakamoto ; ^{koutarou.sakamoto@takeda.com} ; Satoshi Sogabe ; Yusuke Kamada ; Shin-ichi Matsumoto ; Akito Kadotani ; Jun-ichi Sakamoto ; Akiyoshi Tani
• 关键词：Peptide ; Inhibitor ; GPX4 ; Crystal structure ; Phage display
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：195-201
• 全文大小：1581 K
• 卷排序：482

文摘

This is the first report of GPX4 inhibitory peptides and their structural information. X-ray crystal structure analysis revealed their binding mode and site on GPX4. We identified two binding sites on GPX4.