Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens
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- 作者：André ; s Alloatti1 ; 10 ; Fiorella Kotsias1 ; 2 ; 10 ; Anne-Marie Pauwels3 ; 4 ; Jean-Marie Carpier1 ; Mabel Jouve5 ; Evy Timmerman6 ; 7 ; Luigia Pace1 ; Pablo Vargas1 ; 8 ; Mathieu Maurin1 ; Ulf Gehrmann1 ; Leonel Joannas1 ; Omar I. Vivar1 ; Ana-Maria Lennon-Dumé ; nil1 ; Ariel Savina1 ; 9 ; Kris Gevaert6 ; 7 ; Rudi Beyaert3 ; 4 ; 11 ; Eik Hoffmann1 ; 3 ; 4 ; 11 ; eik.hoffmann@irc.vib-ugent.be" class="auth_mail" title="E-mail the corresponding author ; Sebastian Amigorena1 ; 11 ; sebastian.amigorena@curie.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：antigen presentation ; cross-presentation ; dendritic cell ; GTPase Rab34 ; phagocytosis ; phagosome maturation ; Toll-like receptor 4
- 刊名：Immunity
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：43
- 期：6
- 页码：1087-1100
- 全文大小：4107 K
文摘
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TLR4 engagement of DCs for 16 hr increases cross-presentation in vivo and in vitro
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Phagosomes of maturing DCs recruit less lysosomal enzymes becoming less degradative
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LPS-treated DCs display clustering of lysosomes and reduced phago-lysosomal fusion
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Rab34 controls lysosome organization thus increasing cross-presentation efficiency