Quantitative determination of domperidone in rat plasma by high-performance liquid chromatography with fluorescence detection

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• 作者：Yamamoto ; Koujirou ; Hagino ; Mami ; Kotaki ; Hajime ; Iga ; Tatsuji
• 刊名：Journal of Chromatography B: Biomedical Sciences and Applications
• 出版年：1998
• 出版时间：December 11, 1998
• 年：1998
• 卷：720
• 期：1-2
• 页码：251-255
• 全文大小：75.1 K

文摘

A sensitive and selective analytical method for the determination of domperidone in rat plasma is described. The procedure involves liquid–liquid extraction followed by reversed-phase high-performance chromatographic analysis with fluorometric detection at 282 nm for excitation and 328 nm for emission. The detection limit was 1 ng ml⁻¹ using 1 ml of plasma. This assay procedure should be useful for the pharmacokinetic study of domperidone in small animals such as rats.