Airway pressure and outcome of out-of-hospital cardiac arrest: A prospective observational study

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• 作者：Athanasios Chalkias^a ; ^b ; ^c ; ^{thanoschalkias@yahoo.gr} ; Fotios Pavlopoulos^c ; Anastasios Koutsovasilis^d ; Ernesto d'Aloja^e ; Theodoros Xanthos^b ; ^f
• 关键词：Our-of-hospital cardiac arrest ; Mechanical ventilation ; Airway pressure ; Survival ; Return of spontaneous circulation
• 刊名：Resuscitation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：101-106
• 全文大小：871 K
• 卷排序：110

文摘

To assess the usefulness of airway pressure as predictor of return of spontaneous circulation (ROSC), as well as to investigate the optimized ventilation compression strategy during cardiopulmonary resuscitation (CPR).MethodsIn this prospective observational study, 300 out-of-hospital cardiac arrest victims were intubated and resuscitated with the use of a ventilator. Mean airway pressure (mPaw) was measured at pre-defined phases of CPR.ResultsA significant difference in mPaw was observed between survivors and non-survivors after the onset of the third minute of CPR. An mPaw value of 42.5 mbar during CPR had specificity and sensitivity of 0.788 and 0.804, respectively, for ROSC (AUC = 0.668, p = 0.047). During CPR, we found statistically significant differences in mPaw at phases zero (F = 4.526, p = 0.002), two (F = 4.506, p = 0.002), four (F = 8.187, p < 0.0001), five (F = 2.871, p = 0.024), and six (F = 5.364, p < 0.0001).ConclusionMean airway pressure was higher in survivors. A value of 42.5 mbar was associated with ROSC.