Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones
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- 作者：Anna Mrozek-Wilczkiewicz ; Danuta S. Kalinowski ; Robert Musiol ; Jacek Finster ; Agnieszka Szurko ; Katarzyna Serafin ; Magdalena Knas ; Sishir K. Kamalapuram ; Zaklina Kovacevic ; Josef Jampilek ; Alicja Ratu
- 关键词：Anti-proliferative activity ; Quinazolinone ; Styrylquinazoline
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2010
- 出版时间：1 April 2010
- 年：2010
- 卷：18
- 期：7
- 页码：2664-2671
- 全文大小：452 K
文摘
A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin.