Thrombose coronaire distale compliquant une leuc¨¦mie aigu? lymphoblastique trait¨¦e par asparaginase
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- 作者：J.-B. Fraison ; P. Calvet ; I. Domnisoru ; S. Altamir ; a ; H. Vernhet-Kovacsik ; A. Saad ; P. Gallay ; J.-L. Reny ; P. Berdague
- 关键词：Infarctus du myocarde ; Thrombose coronaire ; Asparaginase ; Leucé ; mie aiguë ; lymphoblastique ; Anticoagulant
- 刊名：Annales de Cardiologie et d'Angeiologie
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：61
- 期：4
- 页码：303-305
- 全文大小：396 K
文摘
A 53-year-old man is treated by l-asparaginase for an acute lymphoblastic leukaemia. He received anti thrombin infusions. A systematic electrocardiogram showed an asymptomatic subepicardium ischemia without troponin elevation. Echocardiography and heart magnetic resonance imaging showed an apical thrombus facing a zone of myocardial necrosis. A thrombus regression was observed under anticoagulation. Atypical and asymptomatic coronary thrombosis may occur following l-asparaginase treatment. Regular electrocardiogram monitoring is proposed along this treatment. Arterial thrombosis associated with anti tumor chemotherapies are reviewed.