Goblet cell response after photorefractive keratectomy and laser in situ keratomileusis

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• 作者：Denise S. Ryan ; MS<sup> ; sup><sup>denise.s.ryan.ctr@mail.mil" class="auth_mail" title="E-mail the corresponding authorsup> ; Kraig S. Bower ; MD ; Rose K. Sia ; MD ; Marie A. Shatos ; PhD ; Robin S. Howard ; MS ; Michael J. Mines ; MD ; Richard D. Stutzman ; MD ; Darlene A. Dartt ; PhD
• 刊名：Journal of Cataract & Refractive Surgery
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：42
• 期：8
• 页码：1181-1189
• 全文大小：727 K

文摘

To determine whether patients without dry eye preoperatively have an altered conjunctival goblet cell density and mucin secretion postoperatively and to explore what factors affect changes in goblet cell density and mucin secretion.

sSec_2">Setting

spara0015">The former Walter Reed Army Medical Center, Washington, DC, USA.

sSec_3">Design

spara0020">Prospective nonrandomized clinical study.

sSec_4">Methods

spara0025">Impression cytology was used to determine conjunctival goblet cell density before and 1 week, 1 month, and 3 months after photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK). The McMonnies questionnaire, Schirmer test, tear breakup time, corneal sensitivity, rose bengal staining, and computerized videokeratoscopy were also performed to assess tear-film and ocular-surface health.

sSec_5">Results

spara0030">The ratio of goblet cell to total cells changed postoperatively from baseline in both groups (P < .001). The most significant change was a median 29% decrease 1 month postoperatively. However, there were no significant differences between groups over time (P = .772). The ratio of filled goblet cell to total goblet cell did not change significantly over the same time period (P = .128), and there were no significant differences between the PRK group and the LASIK group over time (P = .282).

sSec_6">Conclusions

spara0035">Patients without apparent dry eye had an altered conjunctival goblet cell population after PRK or LASIK. The conjunctival goblet cell population tended to decrease in the early postoperative period after either surgery and was most affected by preoperative goblet cell density. The changes in the tear film and ocular surface did not seem to affect goblet cell mucin secretion after either procedure.

sSec_7">Financial Disclosure

spara0040">None of the authors has a financial or proprietary interest in any material or method mentioned.