Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action
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- 作者：Monika Kubackaa ; mfkuback@cyf-kr.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Szczepan Mogilskia ; szczepan.mogilski@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Marek Bednarskib ; marek.bedi.pwbf@interia.pl" class="auth_mail" title="E-mail the corresponding author ; Leszek Nowińskib ; lechu.now@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Magdalena Dudekb ; magda.dudek@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Elżbieta Żmudzkab ; elzbieta.zmudzka@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Agata Siwekc ; agat.siwek@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Anna M. Waszkielewiczd ; awaszkie@cm-uj.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Henryk Maronad ; hen.mar@interia.pl" class="auth_mail" title="E-mail the corresponding author ; Grzegorz Satałae ; satala@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Andrzej Bojarskie ; bojarski@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Barbara Filipeka ; mffilipe@cyf-kr.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Karolina Pytkaa ; karolina.pyka@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Serotonin ; 5-HT1A ; 5-HT2A ; 5-HT3 ; 5-HT7 ; 2-methoxyphenylpiperazine ; Forced swim test
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：28-41
- 全文大小：1014 K
文摘
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The activity of new aroxyalkyl derivatives of 2-methoxyphenylpiperazine was studied.
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The compounds showed significant antidepressant-like activity.
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The compounds interact with 5-HT1A, 5-HT2A, 5-HT3 and 5-HT7 receptors.
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Compound 3 is a partial 5-HT1A receptors agonist displaying multiple activities.
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5-HT1A receptors activation is crucial for compound 3 antidepressant-like activity.