Manifestations of the local gastric immune response in gnotobiotic piglets infected with Helicobacter pylori
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- 作者：Krakowka ; Steven ; Ringler ; Susan S. ; Eaton ; Kathryn A. ; Green ; Wendy B. ; Leunk ; Robert
- 关键词：Gnotobiotics ; Pig ; Gastritis ; CD markers ; Helicobacter pylori
- 刊名：Veterinary Immunology and Immunopathology
- 出版年：1996
- 出版时间：July, 1996
- 年：1996
- 卷：52
- 期：3
- 页码：159-173
- 全文大小：1.39 M
文摘
Helicobacter pylori, a human gastric bacterial pathogen, was inoculated into gnotobiotic piglets and manifestations of the resultant gastric inflammation was analyzed by in situ immunochemistry and flow cytometric analysis of isolated lamina propria leukocytes (LPL) and peripheral blood leukocytes (PBL) recovered from infected and control piglets. Gastric mucosa tissue sections from uninfected control piglets were essentially negative for cluster differentiation- (CD-) positive leukocytes. Failure to isolate significant numbers of LPL from the gastric lamina propria confirmed this observation.