Differential Chromosomal Localization of Centromeric Histone CENP-A Contributes to Nematode Programmed DNA Elimination
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- 作者：Yuanyuan Kang1 ; 3 ; Jianbin Wang1 ; 3 ; Ashley Neff1 ; Stella Kratzer1 ; Hiroshi Kimura2 ; Richard E. Davis1 ; 4 ; richard.davis@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：programmed DNA elimination ; centromere ; holocentromere ; CENP-A ; kinetochore ; CENP-C ; NDC80 ; chromosome segregation ; Ascaris
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：16
- 期：9
- 页码：2308-2316
- 全文大小：3193 K
文摘
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CENP-A genome distribution suggests that Ascaris has holocentric chromosomes
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Genomic regions lost during somatic DNA elimination have reduced CENP-A level
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CENP-A is present in these same genomic regions in the mitotic germline
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Changes in CENP-A localization contribute to programmed DNA elimination