Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance
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- 作者：Wei Nia ; Denis J. Glennb ; David G. Gardnerb ; dgardner@diabetes.ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; niwei78@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; niwei78@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：VDR ; vitamin D receptor ; VDRL/L mice ; VDR gene exon 4-floxed mice ; VDRL/L-Tie-2Cre+ mice ; VDR gene exon 4-floxed mice with Tie-2Cre Tg ; GTT ; glucose tolerance test ; ITT ; insulin tolerance test ; AUC ; area under the curve ; KRBB ; Krebs&ndash ; Ringer bicarbonate buffer
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：281-286
- 全文大小：1218 K
文摘
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We found improved glucose disposal in Tie-2Cre-mediated endothelial/macrophage VDR KO mice.
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Improvement in glucose disposal is due to increased insulin sensitivity in skeletal muscle not in liver.
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Reduced insulin secretion is likely secondary to improved insulin sensitivity.