Distinct Functions of α₃ and α_V Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex

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• 作者：E.S Anton ; Jordan A Kreidberg ; Pasko Rakic
• 刊名：Neuron
• 出版年：1999
• 出版时间：February 1999
• 年：1999
• 卷：22
• 期：2
• 页码：277-289
• 全文大小：424 K

文摘

Changes in specific cell–cell recognition and adhesion interactions between neurons and radial glial cells regulate neuronal migration as well as the establishment of distinct layers in the developing cerebral cortex. Here, we show that α₃β₁ integrin is necessary for neuron–glial recognition during neuronal migration and that α_V integrins provide optimal levels of the basic neuron–glial adhesion needed to maintain neuronal migration on radial glial fibers. A gliophilic-to-neurophilic switch in the adhesive preference of developing cortical neurons occurs following the loss of α₃β₁ integrin function. Furthermore, the targeted mutation of the α₃ integrin gene results in abnormal layering of the cerebral cortex. These results suggest that α₃β₁ and α_V integrins regulate distinct aspects of neuronal migration and neuron–glial interactions during corticogenesis.