Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA)

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• 作者：José ; R Mediavilla ; Liang Chen ; Barun Mathema ; Barry N Kreiswirth ^{kreiswba@umdnj.edu}
• 刊名：Current Opinion in Microbiology
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：15
• 期：5
• 页码：588-595
• 全文大小：412 K

文摘

During the 1990s, various reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections appeared in the literature, caused by novel strains genetically distinct from traditional healthcare-associated MRSA (HA-MRSA). Numerous lineages of CA-MRSA have since emerged on every continent, several of which have spread internationally, most notably USA300. CA-MRSA strains are increasingly implicated in nosocomial infections, and may eventually displace HA-MRSA strains in hospitals. Consequently, distinctions based on clinical epidemiology and susceptibility are becoming less relevant, arguing in favor of genotypic definitions. We review the current molecular epidemiology of CA-MRSA with respect to genetic diversity, global distribution, and factors related to its emergence and spread.