Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives
详细信息 查看全文
- 作者：Krishna C. Bulusu1 ; kcb27@cam.ac.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Rajarshi Guha2Author Vitae ; Daniel J. Mason1 ; Richard P.I. Lewis1 ; Eugene Muratov3 ; Yasaman Kalantar Motamedi1 ; Murat Cokol4 ; Andreas Bender1 ; ab454@cam.ac.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 刊名：Drug Discovery Today
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：21
- 期：2
- 页码：225-238
- 全文大小：749 K
文摘
- •
Review of the state-of-the-art in the field of compound combination modelling.
- •
Significance of quality control of large-scale combination screening data.
- •
Strategies for modelling combination effects using publicly available resources.
- •
Importance of chemical and biological data integration for predictions.
- •
Technical and scientific challenges of data integration in this context are discussed.