Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids

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• 作者：Valerian E. Kagan^a ; ^b ; ^c ; ^d ; ^f ; ^{kagan@pitt.edu} ; Hü ; lya Bayır^a ; ^b ; ^e ; Yulia Y. Tyurina^a ; ^b ; Sergey B. Bolevich^f ; John J. Maguire^a ; ^b ; Bengt Fadeel^g ; Krishnakumar Balasubramanian^a ; ^b
• 关键词：Phosphatidylserine signaling ; Cardiolipin signaling ; Cardiolipin oxidation ; Phosphatidylserine oxidation ; Mitophagy ; Phagocytosis ; Apoptosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：482
• 期：3
• 页码：482-490
• 全文大小：1020 K
• 卷排序：482

文摘

Phospholipid (PL) signaling in elimination of organelles and cells is reviewed. Anionic PL membrane asymmetry generates distinct signals for elimination. Oxidation of cardiolipin is a required stage in mitochondrial apoptosis. Oxidation of externalized phosphatidylserine enhances phagocytosis efficiency.