Prognostic Impact of the Presence and Absence of Angina on Mortality and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Stable Coronary Artery Disease: Results from the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes)

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• 作者：Gilles R. Dagenais ; MD^? ; ^{gilles.dagenais@criucpq.ulaval.ca} ; Jiang Lu ; MS^&dagger ; ; David P. Faxon ; MD^&Dagger ; ; Peter Bogaty ; MD^? ; Dale Adler ; MD^&Dagger ; ; Francisco Fuentes ; MD^§ ; ; Jorge Escobedo ; MD^¡Î ; Ashok Krishnaswami ; MD^¶ ; ; James Slater ; MD^# ; Robert L. Frye ; MD^?? ; BARI 2D Study Group
• 关键词：angina ; coronary artery disease ; silent ischemia ; type 2 diabetes
• 刊名：Journal of the American College of Cardiology
• 出版年：2013
• 出版时间：19 February, 2013
• 年：2013
• 卷：61
• 期：7
• 页码：702-711
• 全文大小：1009 K

文摘

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Objectives

The purpose of this analysis was to assess in patients with type 2 diabetes and stable coronary artery disease (CAD) whether the risk of all-cause mortality and cardiovascular events varied according to the presence or absence of angina and angina equivalent symptoms.

Background

Data on the prognostic value of symptoms in these patients are limited.

Methods

Post-hoc analysis was performed in 2,364 patients with type 2 diabetes and documented CAD enrolled in the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial to determine the occurrence of death and composite of death, myocardial infarction, and stroke during a 5-year follow-up according to cardiac symptoms at baseline.

Results

There were 1,434 patients with angina (A), 506 with angina equivalents (E), and 424 with neither of these (N). The cumulative death rates (total 316) were 12 % in A, 14 % in E, and 10 % in N (p = 0.3), and cardiovascular composite rates (total 548) were 24 % in A, 24 % in E, and 21 % in N (p = 0.5). Compared with N, the hazard ratios adjusted for confounders were not different for death in A (1.11; 99 % CI: 0.81 to 1.53) and E (1.17; 99 % CI: 0.81 to 1.68) or for cardiovascular events in A (1.17; 99 % CI: 0.92 to 1.50) and E (1.11; 99 % CI: 0.84 to 1.48).

Conclusions

Whatever their symptom status, patients with type 2 diabetes and stable CAD were at similar risk of cardiovascular events and death. These findings suggest that these patients may be similarly managed in terms of risk stratification and preventive therapies. (Bypass Angioplasty Revascularization Investigation 2 Diabetes [BARI 2D]; )