Characterization of ovarian cancer cell lines as in vivo models for preclinical studies
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- 作者：Lidia Hernandez1 ; Marianne K. Kim1 ; L. Tiffany Lyle ; Kristen P. Bunch2 ; Carrie D. House ; Franklin Ning ; Anne M. Noonan3 ; Christina M. Annunziata ; annunzic@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ovarian cancer ; Xenografts ; Cell lines ; Mouse model
- 刊名：Gynecologic Oncology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：142
- 期：2
- 页码：332-340
- 全文大小：1822 K
文摘
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Human cell line xenografts provide a valuable tool for studying cancer biology and response to treatments.
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Characterizing growth conditions in mice can speed translation of in vitro work to in vivo testing.
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The tumorigenicity of 17 human ovarian cancer cell lines is variable, and may reflect differing biology of each individual model.