Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma
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- 作者：Patrick J. Grohar1 ; 2 ; 3 ; 10 ; Suntae Kim4 ; 10 ; Guillermo O. Rangel Rivera4 ; 6 ; Nirmalya Sen4 ; Sara Haddock4 ; Matt L. Harlow3 ; Nichole K. Maloney1 ; Jack Zhu5 ; Maura O&rsquo ; Neill7 ; Tamara L. Jones4 ; Konrad Huppi4 ; Magdalena Grandin4 ; Kristen Gehlhaus4 ; Carleen A. Klumpp-Thomas8 ; Eugen Buehler8 ; Lee J. Helman9 ; Scott E. Martin8 ; Natasha J. Caplen4 ; ncaplen@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：14
- 期：3
- 页码：598-610
- 全文大小：4970 K
文摘
Expression of EWS-FLI1 requires specific RNA processing proteins
HNRNPH1 is required for the splicing of EWS-FLI1 pre-mRNAs containing EWSR1 exon 8
Inhibition of SF3B1 results in mis-splicing of the EWS-FLI1 transcript
RNA processing is a potential therapeutic vulnerability in Ewing sarcoma