The secreted form of the WNV NS1 protein (sNS1) inhibits TLR signaling.
sNS1 inhibits TLR3 in HeLa cells, TLR4 and TLR7 in macrophages and dendritic cells.
sNS1 inhibits the cytokine response to infection in mouse macrophages.
sNS1 associates with macrophages and dendritic cells in vivo.
sNS1 inhibits the cytokine response to WNV replicon particle infection vivo.