- 作者：Zachary D. Guss A.B.&lowast ; ; Sachin Batra M.B.B.S. ; M.P.H.&lowast ; ; Charles J. Limb M.D.&dagger ; ; Gordon Li M.D.&Dagger ; ; Michael E. Sughrue M.D.§ ; ; Kristin Redmond M.D.¶ ; ; Daniele Rigamonti M.D.&lowast ; ; Andrew T. Parsa M.D. ; Ph.D.§ ; ; Steven Chang M.D.&Dagger ; ; Lawrence Kleinberg M.D.¶ ; ; Michael Lim M.D.&lowast ; ; ; mlim3@jhmi.edu
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2011
- 出版时间：15 November 2011
- 年：2011
- 卷：81
- 期：4
- 页码：e497-e502
- 全文大小：360 K
Purpose
During the past two decades, radiosurgery has arisen as a promising approach to the management of glomus jugulare. In the present study, we report on a systematic review and meta-analysis of the available published data on the radiosurgical management of glomus jugulare tumors.Methods and Materials
To identify eligible studies, systematic searches of all glomus jugulare tumors treated with radiosurgery were conducted in major scientific publication databases. The data search yielded 19 studies, which were included in the meta-analysis. The data from 335 glomus jugulare patients were extracted. The fixed effects pooled proportions were calculated from the data when Cochrane's statistic was statistically insignificant and the inconsistency among studies was <25 % . Bias was assessed using the Egger funnel plot test.
Results
Across all studies, 97 % of patients achieved tumor control, and 95 % of patients achieved clinical control. Eight studies reported a mean or median follow-up time of >36 months. In these studies, 95 % of patients achieved clinical control and 96 % achieved tumor control. The gamma knife, linear accelerator, and CyberKnife technologies all exhibited high rates of tumor and clinical control.
Conclusions
The present study reports the results of a meta-analysis for the radiosurgical management of glomus jugulare. Because of its high effectiveness, we suggest considering radiosurgery for the primary management of glomus jugulare tumors.