Connective tissue growth factor level is increased in patients with liver cirrhosis but is not associated with complications or extent of liver injury

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• 作者：Sabrina Bauer ; Kristina Eisinger ; Reiner Wiest ; Thomas Karrasch ; Marcus N. Scherer ; Stefan Farkas ; Charalampos Aslanidis ; Christa Buechler
• 关键词：Hepatic vein ; TIPS ; CHILD-PUGH stage ; CTGF
• 刊名：Regulatory Peptides
• 出版年：2012
• 出版时间：10 November, 2012
• 年：2012
• 卷：179
• 期：1-3
• 页码：10-14
• 全文大小：413 K

文摘

Connective tissue growth factor (CTGF) is a profibrotic protein whose systemic levels are increased in liver cirrhosis. Here, association of CTGF with stages of liver injury and complications of cirrhotic liver disease has been analyzed in patients with different aetiologies of hepatic injury. CTGF is significantly increased in portal venous serum (PVS), hepatic venous serum (HVS) and systemic venous serum (SVS) of 46 patients with liver cirrhosis compared to eight liver-healthy controls. In patients¡ä blood samples CTGF in HVS is about 6 % higher than PVS levels indicating that CTGF produced in the liver is released to the circulation. CTGF is not associated with stages of liver cirrhosis defined by CHILD-PUGH or MELD score nor with secondary complications of portal hypertension (varices, ascites, spontaneous bacterial peritonitis). Transforming growth factor ¦Â (TGF¦Â) induces CTGF synthesis in hepatocytes and a positive association of systemic TGF¦Â1 and SVS and HVS CTGF is found. Three months after placing transjugular intrahepatic portosystemic shunt (TIPS) hepatic venous pressure gradient is reduced whereas CHILD-PUGH score, TGF¦Â1 and CTGF are not altered in serum of 15 patients. Current data show that the cirrhotic liver releases little CTGF but SVS, HVS and PVS CTGF levels are not associated with residual liver function and complications of cirrhosis.