Image noise was significantly reduced at low keV-levels with the novel monoenergetic algorithm.
Tumor contrast-to-noise ratio peaked in the 40/55 keV series reconstructed with the novel algorithm.
Tumor signal-to-noise and contrast-to-noise ratios were higher with noise-optimized VMI+ compared to traditional VMI.
Subjective image quality ratings were highest for the 55 keV series reconstructed with the novel algorithm.
The novel algorithm for monoenergetic dual-energy CT may improve visualization of lung cancer.