Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3

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• 作者：Milberg ; Peter ; Reinsch ; Nico ; Wasmer ; Kristina ; M??nnig ; Gerold ; Stypmann ; J??rg ; Osada ; Nani ; et. al.
• 关键词：Torsade de pointes ; Long QT syndrome ; Action potential ; prolongation ; Transmural dispersion ; Veratridine
• 刊名：Cardiovascular Research
• 出版年：2005
• 出版时间：February 1, 2005
• 年：2005
• 卷：65
• 期：2
• 页码：397-404
• 全文大小：349 K

文摘

Congenital and acquired long QT syndrome (LQTS) are caused by abnormalities of ionic currents underlying ventricular repolarization. For a better understanding of the mechanisms by which functional electrical instability at the level of the whole heart leads to torsade de pointes (TdP), a novel model of LQT3 was developed and the role of transmural dispersion of repolarization for the development of proarrhythmia was evaluated.