Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl− current in canine ventricular myocytes
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- 作者：Balá ; zs Horvá ; tha ; b ; 1 ; Krisztina Vá ; czia ; 1 ; Bence Hegyia ; Mó ; nika Gö ; nczia ; c ; Beatrix Dienesa ; Korné ; l Kistamá ; sa ; Tamá ; s Bá ; nyá ; sza ; Já ; nos Magyara ; d ; Istvá ; n Baczkó ; e ; Andrá ; s Varró ; e ; f ; Gyö ; rgy Sepré ; nyig ; Lá ; szló ; Csernocha ; Pé ; ter P. Ná ; ná ; sia ; h ; Norbert Szentandrá ; ssya ; h ; szentandrassy.norbert@med.unideb.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：9-AC ; 9-anthracene carboxylic acid ; AP ; action potential ; APVC ; action potential voltage-clamp ; APD90 ; action potential duration at 90% of repolarization ; BKCa ; large-conductance Ca2+-activated K+ channels ; CaT ; calcium transient ; Cav1.2 ; pore forming subunit of L-type Ca2+ channel ; [Ca2+]cleft ; Ca2+ concentration in the dyadic cleft ; [Ca2+]i ; intracellular Ca2+ concentration in bulk cytoplasm ; [Cl&minus ; ]i ; intracellular Cl&minus ; concentration ; CDI ; Ca2+-dependent inactivation ; CICR ; Ca2+-indu
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：125-139
- 全文大小：2150 K
文摘
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Ca2+-entry via ICa,L is essential for the activation of ICl(Ca).
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ICl(Ca) can be activated even in the absence of CICR.
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TMEM16A and Bestrophin-3 are expressed on human left ventricular muscle.
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TMEM16A and Bestrophin-3 co-localize with each other and with Cav1.2 channels.
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Only BAPTA but not EGTA can buffer effectively [Ca2+]cleft.