Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

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• 作者：Divya Jayaraman¹ ; ² ; ³ ; ⁴ ; ⁵ ; ¹⁵ ; Andrew Kodani⁶ ; ¹⁵ ; Dilenny M. Gonzalez¹ ; ² ; ³ ; Joseph D. Mancias⁷ ; ⁸ ; Ganeshwaran H. Mochida¹ ; ² ; ⁹ ; ¹⁰ ; Cristiana Vagnoni¹¹ ; Jeffrey Johnson¹² ; Nevan Krogan¹² ; J. Wade Harper⁷ ; Jeremy F. Reiter⁶ ; Timothy W. Yu¹ ; ⁹ ; ¹³ ; ^{timothy.yu@childrens.harvard.edu} ; Byoung-il Bae¹ ; ² ; ³ ; ¹⁶ ; ^{byoung-il.bae@yale.edu} ; Christopher A. Walsh¹ ; ² ; ³ ; ⁴ ; ⁹ ; ¹³ ; ¹⁴ ; ¹⁷ ; ^{christopher.walsh@childrens.harvard.edu}
• 关键词：Wdr62 ; Aspm ; maternal centriole ; apical complex
• 刊名：Neuron
• 出版年：2016
• 出版时间：23 November 2016
• 年：2016
• 卷：92
• 期：4
• 页码：813-828
• 全文大小：6016 K
• 卷排序：92

文摘

Wdr62 and Aspm interact genetically to control brain size in mice Loss of Wdr62 or Aspm causes centriole duplication defects proportional to microcephaly WDR62 and ASPM are maternal centriolar proteins that recruit CPAP to the centrosome Loss of Wdr62 and Aspm causes gene dose-dependent disruption of the apical complex