EQCM verification of the concept of drug immobilization and release from conducting polymer matrix
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- 作者：Katarzyna Krukiewicza ; katarzyna.krukiewicz@polsl.pl" class="auth_mail" title="E-mail the corresponding author ; Barbara Bednarczyk-Cwynarb ; bcwynar@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Roman Turczyna ; roman.turczyn@polsl.pl" class="auth_mail" title="E-mail the corresponding author ; Jerzy K. Zaka ; 1 ; jerzy.zak@polsl.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：drug delivery ; conducting polymers ; electrochemical quartz crystal microbalance ; betulin ; PEDOT
- 刊名：Electrochimica Acta
- 出版年：2016
- 出版时间：10 September 2016
- 年：2016
- 卷：212
- 期：Complete
- 页码：694-700
- 全文大小：1251 K
文摘
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Disuccinyl derivative of anti-cancer drug, betulin, was immobilized in PEDOT matrix.
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EQCM was used to monitor the processes of drug immobilization and release.
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SEM, EDS and IR confirmed the presence of drug in polymer matrix.
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The release of drug was performed with and without application of external potential.
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Potentiodynamic stimulation was more efficient that potentiostatic release.