Vena Caval Filter Utilization and Outcomes in Pulmonary Embolism: Medicare Hospitalizations From 1999 to 2010

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• 作者：Behnood Bikdeli ; MD^a ; ^e ; Yun Wang ; PhD^a ; ^f ; Karl E. Minges ; MPH^a ; ^g ; Nihar R. Desai ; MD ; MPH^a ; ^b ; Nancy Kim ; MD ; PhD^a ; ^c ; Mayur M. Desai ; PhD ; MPH^a ; ^d ; ^h ; John A. Spertus ; MD ; MPH^j ; ^k ; Frederick A. Masoudi ; MD ; MSPH^l ; Brahmajee K. Nallamothu ; MD ; MPH^m ; Samuel Z. Goldhaber ; MDⁿ ; ^o ; Harlan M. Krumholz ; MD ; SM^a ; ^b ; ^d ; ⁱ ; ^{harlan.krumholz@yale.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：deep vein thrombosis ; mortality ; trends
• 刊名：Journal of the American College of Cardiology
• 出版年：2016
• 出版时间：8 March 2016
• 年：2016
• 卷：67
• 期：9
• 页码：1027-1035
• 全文大小：1103 K

文摘

Inferior vena caval filters (IVCFs) may prevent recurrent pulmonary embolism (PE). Despite uncertainty about their net benefit, patterns of use and outcomes of these devices in contemporary practice are unknown.

Objectives

The authors determined the trends in utilization rates and outcomes of IVCF placement in patients with PE and explored regional variations in use in the United States.

Methods

In a national cohort study of all Medicare fee-for-service beneficiaries ≥65 years of age with principal discharge diagnoses of PE between 1999 and 2010, rates of IVCF placement per 100,000 beneficiary-years and per 1,000 patients with PE were determined. The 30-day and 1-year mortality rates after IVCF placement were also investigated.

Results

Among 556,658 patients hospitalized with PE, 94,427 underwent IVCF placement. Between 1999 and 2010, the number of PE hospitalizations with IVCF placement increased from 5,003 to 8,928, representing an increase in the rate per 100,000 beneficiary-years from 19.0 to 32.5 (p < 0.001 for both). As the total number of PE hospitalizations increased (from 31,746 in 1999 to 54,392 in 2010), the rate of IVCF placement per 1,000 PE hospitalizations did not change significantly (from 157.6 to 164.1, p = 0.11). Results were consistent across demographic subgroups, although IVCF use was higher in blacks and patients ≥85 years of age. IVCF utilization varied widely across regions, with the highest rate in the South Atlantic region and the lowest rate in the Mountain region.

Conclusions

In a period of increasing PE hospitalizations among Medicare fee-for-service beneficiaries, IVCF placement increased as utilization rates in patients with PE remained greater than 15%. Mortality associated with PE hospitalizations is declining, regardless of IVCF use.