- 作者：Andrea Tringali ; Paul Didden ; Aless ; ro Repici ; Manon Spa ; er ; Michael J. Bourke ; Stephen J. Williams ; Julius Spicak ; Pavel Drastich ; Massimiliano Mutignani ; Vincenzo Perri ; Andr茅 Roy ; Krystal Johnston ; Guido Costamagna
- 关键词：GJJ ; gastrojejunostomy ; GOOSS ; gastric outlet obstruction scoring system
- 刊名：Gastrointestinal Endoscopy
- 出版年：January, 2014
- 年：2014
- 卷：79
- 期：1
- 页码：66-75
- 全文大小：1045 K
Background
Malignant gastric outlet obstruction is often treated by stent placement.Objective
To investigate the outcomes of stent placement in the palliative treatment of malignant neoplasms.
Design
Prospective, observational, multicenter registry.
Setting
Six tertiary care centers in 5 countries.
Patients
A total of 108 adult patients with malignant gastric outlet obstruction.
Interventions
Placement of an uncovered, self-expandable, metal duodenal stent.
Main Outcome Measurements
The primary endpoint was stent patency at 14 days after stent implantation. Secondary endpoints included stent patency at 1, 2, 3, and 6 months, gastric outlet obstruction scoring system (GOOSS) scores at 14 days and 1, 2, 3, and 6 months after stent deployment, technical success, adverse events, and patient survival (ie, confirmed duration of the implant).
Results
Technical success was achieved in 99.1% of stent placements. Stent patency at 14 days was 94.6%. Kaplan-Meier estimates of stent patency were 92.9% at 1 month, 86.2% at 2 months, 81.9% at 3 months, and 63.4% at 6 months. At 14 days, GOOSS scores increased by a median of 1 point. The overall GI adverse event rate was 32.4%; however, the stent-related adverse event rate was 19.4%. The median implant duration was 47聽days (range 0-195 days).
Limitations
Observational study, no control group.
Conclusions
Duodenal stent placement resulted in prompt relief of malignant gastric outlet obstruction and improved GOOSS scores. (Clinical trial registration number: .)