Components of the lectin pathway of complement activation in paediatric patients of intensive care units
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- 作者：Anna S. Świerzkoa ; Agnieszka Szala-Poździeja ; David C. Kilpatrickb ; Michał Sobocińskic ; Karolina Chojnackad ; Anna Sokołowskaa ; Mateusz Michalskia ; e ; Karolina Mazeranta ; Jens C. Jenseniusf ; Misao Matsushitag ; Wojciech R. Krajewskic ; Jerzy Szczapad ; Leokadia Bąk-Romaniszynh ; Krzysztof Zemani ; Maciej Cedzyńskia ; mcedzynski@cbm.pan.pl" class="auth_mail" title="E-mail the corresponding author ; mcedzyns@poczta.onet.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：MASP ; mannose-binding lectin-associated serine protease ; MBL ; mannose-binding lectin ; SIRS ; systemic inflammatory response syndrome
- 刊名：Immunobiology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：221
- 期：5
- 页码：657-669
- 全文大小：1773 K
文摘
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Low MBL-conferring genotypes (LXA/O + O/O) were associated with paediatric sepsis.
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Low serum MBL, ficolin-2 and -3 on admission were associated with paediatric sepsis.
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Low ficolin-3 seemed to be associated with higher mortality from neonatal sepsis.
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No impact of SNPs of FCN1, FCN2, FCN3, MASP1/3, MASP2, TLR2, TLR4 genes was found.