Oximinoalkylamines as ligands for Cu-assisted azide-acetylene cycloaddition

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• 作者：Artem N. Semakin^a ; ^b ; ^{artyomsemakin@mail.ru" class="auth_mail" title="E-mail the corresponding author} ; Daniil P. Agababyan^b ; Sohee Kim^c ; Sangyoon Lee^c ; Alexey Yu. Sukhorukov^a ; ^{sukhorukov@ioc.ac.ru" class="auth_mail" title="E-mail the corresponding author} ; Ksenia G. Fedina^b ; Jinho Oh^c ; Sema L. Ioffe^a ; ^b
• 关键词：CuAAC ; Click-chemistry ; Ligands ; Poly(oximinoalkyl)amines
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：18 November 2015
• 年：2015
• 卷：56
• 期：46
• 页码：6335-6339
• 全文大小：2324 K

文摘

Oximinoalkylamines were found to be efficient ligands for acceleration of the CuAAC reaction. ‘Mixed’ oxime–triazole ligands Tz^尾Ox₂ and Tz₂^尾Ox demonstrate an approximately 10-fold enhanced acceleration effect compared to commonly employed ligand TBTA using 0.1 mol % of the [Cu]/L catalytic system. The optimal catalytic system based on readily available Tz^尾Ox₂ provided 1,4-disubstituted triazoles in high yields with short reaction times.