Toll-interacting protein inhibits HIV-1 infection and regulates viral latency
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- 作者：Chuan Li ; Wen-Dong Kuang ; Di Qu ; Jian-Hua Wang ; jh_wang@sibs.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV-1 ; Long-terminal repeat ; Toll-interacting protein ; Viral latency
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：24 June 2016
- 年：2016
- 卷：475
- 期：2
- 页码：161-168
- 全文大小：1748 K
文摘
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Knock-down of Tollip promotes HIV-1 reactivation from latency.
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Knock-down of Tollip increases HIV-1 transcription and infection in primary CD4+ T cells.
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Tollip represses the activities of LTRs derived from multiple HIV-1 subtypes.