A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy

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• 作者：Mei-Rong Ke^a ; Shao-Fang Chen^a ; Xiao-Hui Peng^a ; Qiao-Feng Zheng^a ; Bi-Yuan Zheng^a ; Chih-Kuang Yeh^b ; Jian-Dong Huang^a ; ^{jdhuang@fzu.edu.cn}
• 关键词：Cancer ; Prodrugs ; Chemo-photodynamic therapy ; Doxorubicin ; Phthalocyanine ; Fibroblast activation protein
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：200-209
• 全文大小：1440 K
• 卷排序：127

文摘

A novel phthalocyanine-tetrapeptide-doxorubicin prodrug has been synthesized. Both photosensitizing activity and cytotoxicity of the conjugate are inhibited. It can be activated by fibroblast activation protein both in vitro and in vivo. The prodrug shows a synergistic anticancer efficacy against HepG2 cells.