Molecular structure and chemical properties of two pregnanes were tested in sex inhibition.
Both 5α- and 5β-pregnanediones elicited concurrent inhibition (CI) of the lordosis reflex.
The extent of the concurrent inhibition was different for both pregnanes, favoring 5α-DHP.
The CI of the sex response was related to the pregnane structure and chemical properties.
It is proposed that both pregnanes may act as hormones in the central nervous system.