The importance of the chemical structure of pregnanes in the concurrent inhibition of estrous behavior in the female rat
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- 作者：Carlos Kubli-Garfiasa ; kubli@unam.mx" class="auth_mail" title="E-mail the corresponding author ; Francisco J. Lima-Herná ; ndezb ; Ricardo Vá ; zquez-Ramí ; reza ; Porfirio Gó ; mora-Arratib ; Marcos Garcí ; a-Juá ; rezb ; Oscar Gonzá ; lez-Floresb
- 关键词：5α-DHP ; 5α-pregnanedione or 5α-dihydroprogesterone ; 5β-DHP ; 5β-pregnanedione or 5β-dihydroprogesterone ; P ; progesterone ; ovx ; ovariectomized ; E2 ; estradiol ; EB ; estradiol benzoate ; DM ; dipole moment ; ANOVA ; analysis of variance ; CNS ; central nervous system ; sc ; subcutaneous ; icv ; intracerebroventricular ; LQ ; lordosis quotient ; RMSD ; root mean square deviation ; PR ; progesterone receptor
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：51-58
- 全文大小：1711 K
文摘
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Molecular structure and chemical properties of two pregnanes were tested in sex inhibition.
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Both 5α- and 5β-pregnanediones elicited concurrent inhibition (CI) of the lordosis reflex.
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The extent of the concurrent inhibition was different for both pregnanes, favoring 5α-DHP.
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The CI of the sex response was related to the pregnane structure and chemical properties.
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It is proposed that both pregnanes may act as hormones in the central nervous system.