Small-animal PET: A promising, non-invasive tool in pre-clinical research
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- 作者：Uta Schnö ; ckel ; Sven Hermann ; Lars Stegger ; Marilyn Law ; Michael Kuhlmann ; Otmar Schober ; Klaus Schä ; fers ; Michael Schä ; fers
- 关键词：Small-animal PET ; Nuclear medicine ; Pre-clinical research ; Molecular imaging
- 刊名：European Journal of Pharmaceutics and Biopharmaceutics
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：74
- 期：1
- 页码：50-54
- 全文大小：1137 K
文摘
Today, non-invasive imaging techniques are significantly contributing to the understanding of molecular processes in vivo. Positron emission tomography (PET) is a scintigraphic medical imaging modality that uses radiolabelled molecules (tracers), provides quantitative tomographic images and allows non-invasive assessment of the biodistribution of radioactive substances in vivo. The assessment of pathological glucose metabolism is the clinically best-established application of PET today; however, a multitude of different tracers are available to assess diverse physiological processes. The growing interest in pre-clinical imaging studies, in biological and medical basic research, as well as in pharmaceutical research, has fostered the recent growth in small-animal PET. Small-animal PET can be applied to enable the transfer from molecular findings in vitro to in vivo applications in humans, from bench to bed side.