Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
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- 作者：Rita M.L. La Rovere1 ; Gemma Roest1 ; Geert Bultynck ; geert.bultynck@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Jan B. Parys ; jan.parys@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Autophagy ; Endoplasmic reticulum ; IP3 receptor ; Lysosomes ; Mitochondria
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：60
- 期：2
- 页码：74-87
- 全文大小：1572 K
文摘
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Various Ca2+ microdomains exist in living cells.
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Basal Ca2+ transfer between ER and mitochondria enhances cellular bioenergetics.
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Excessive Ca2+ transfer between ER and mitochondria induces apoptosis.
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Ca2+ release from the ER and from the lysosomes regulates autophagy.
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Ca2+ microdomains critically control cell survival and cell death decisions.