Waist Circumference Percentiles in 2-18 Year Old Indian Children

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• 作者：Anuradha Khadilkar ; MD¹ ; ^{anuradhavkhadilkar@gmail.com" class="auth_mail} ; Veena Ekbote ; MSc¹ ; Shashi Chiplonkar ; PhD¹ ; Vaman Khadilkar ; MRCP¹ ; Neha Kajale ; MSc¹ ; Surabhi Kulkarni ; MSc¹ ; Lavanya Parthasarathy ; MSc¹ ; Archana Arya ; DNB² ; Anjan Bhattacharya ; MRCPCH (UK)³ ; Sanwar Agarwal ; MD⁴
• 关键词：BAZ ; Body mass index for age z-score ; BMI ; Body mass index ; BP ; Blood pressure ; DBP ; Diastolic blood pressure ; HAZ ; Height for age z-score ; HDL ; High-density lipoprotein ; LDL ; Low-density lipoprotein ; MS ; Metabolic syndrome ; NHANES ; National Health and Nutrition Examination Survey ; ROC ; Receiver operating characteristic ; SBP ; Systolic blood pressure ; WAZ ; Weight for age z-score ; WC ; Waist circumference
• 刊名：The Journal of Pediatrics
• 出版年：June 2014
• 年：2014
• 卷：164
• 期：6
• 页码：1358-1362.e2
• 全文大小：752 K

文摘

To develop reference percentile curves in Indian children for waist circumference (WC), and to provide a cutoff of WC percentile to identify children at risk for metabolic syndrome (MS).

Study design

A multicenter, cross-sectional study was performed in 5 major Indian cities. Height, weight, and blood pressure (BP) were measured in 10鈥?42 children (6065 boys). Elevated BP was defined as either systolic BP or diastolic BP >95th percentile. WC was measured with the child standing using a stretch-resistant tape. Sex-specific reference percentiles were computed using the LMS method which constructs reference percentiles adjusted for skewness. To determine optimal cutoffs for WC percentiles, a validation sample of 208 children was assessed for MS risk factors (ie, anthropometry, BP, blood lipids), and receiver operating characteristic (ROC) curve analysis was performed.

Results

Age- and sex-specific WC percentiles (5th, 10th, 15th, 25th, 50th, 75th, 85th, 90th, and 95th) are presented. WC values increased with age in both the boys and the girls. The median WC at age >15 years was greater in boys compared with girls. ROC analysis suggested the 70th percentile as a cutoff for MS risk (sensitivity, 0.84 in boys and 0.82 in girls; specificity, 0.85 in both boys and girls; area under the ROC curve, 0.88 in boys and 0.92 in girls).

Conclusion

Age- and sex-specific reference curves for WC for Indian children and cutoff values of 70th WC percentile for screening for MS risk are provided.