Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin
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- 作者：Mahantesha Basanagouda ; K. Shivashankar ; Manohar V. Kulkarni ; Vijaykumar P. Rasal ; Harishch ; ra Patel ; Sumit S. Mutha ; Ashwini A. Mohite
- 关键词：Coumarin ; Sulfonamide ; Azide ; Antimicrobial activity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2010
- 出版时间：March 2010
- 年：2010
- 卷：45
- 期：3
- 页码：1151-1157
- 全文大小：183 K
文摘
A series of new and novel coumarin-6-sulfonamides with a free C4-azidomethyl group have been synthesized as antimicrobials in three steps starting from 7-methyl-4-bromomethylcoumarin 1. The reaction of 1 with chlorosulfonic acid was found to yield the corresponding 6-sulfonylchloride 2, which when treated with sodium azide led to intermediate 3. The title sulfonamides 5a–y were obtained from the reaction of 3 with various aromatic amines 4 in refluxing benzene. The chemical structures of the compounds were elucidated by IR, NMR and LC-MS spectral data. All the synthesized compounds have been screened for their in vitro anti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against both bacterial species at a concentration of 1 μg/mL.