Diverse roles of ANGPTL2 in physiology and pathophysiology
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- 作者：Tsuyoshi Kadomatsu1 ; Motoyoshi Endo1 ; Keishi Miyata1 ; Yuichi Oike1 ; 2 ; oike@gpo.kumamoto-u.ac.jp" class="auth_mail
- 关键词：angiopoietin-like protein 2 ; tissue repair ; chronic inflammation ; tissue remodeling ; circadian rhythm ; lifestyle disease
- 刊名：Trends in Endocrinology and Metabolism
- 出版年：May 2014
- 年：2014
- 卷：25
- 期：5
- 页码：245-254
- 全文大小：1132 K
文摘
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Tissue damage is repaired by inflammation and subsequent physiological tissue remodeling, a phenomenon called tissue homeostasis.
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ANGPTL2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction.
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Excess ANGPTL2 signaling causes chronic inflammation and irreversible tissue remodeling, promoting development of lifestyle diseases.
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Blocking excess ANGPTL2 signaling could represent novel and effective therapeutic strategies against lifestyle diseases.