Development of chitosan-based nanoparticles through inter-polymeric complexation for oral drug delivery

详细信息    查看全文

• 作者：Sougata Jana ; Nirmal Maji ; Amit Kumar Nayak ; Kalyan Kumar Sen ; Sanat Kumar Basu
• 关键词：Chitosan ; Nanoparticles ; Sustained release ; Drug delivery ; Alprazolam
• 刊名：Carbohydrate Polymers
• 出版年：2013
• 出版时间：15 October, 2013
• 年：2013
• 卷：98
• 期：1
• 页码：870-876
• 全文大小：2074 K

文摘

The possibility of inter-polymeric complexation of cationic chitosan and anionic egg albumin stabilized with PEG 400 to develop novel nanoparticles for oral delivery of alprazolam by heat coagulation method at pH 5.4 and 80 ¡ãC. Nine formulations were prepared by changing the concentration of chitosan, PEG 400 and heating time. The alprazolam entrapment efficiency of these nanoparticles was in the range of 68.12 ¡À 1.27 to 99.37 ¡À 4.86 % . These nanoparticles were characterized by FTIR, DSC, P-XRD and FE-SEM analysis. Average particle diameter, poly-dispersity index and zeta potential of these nanoparticles were found 259.60 nm, 0.501, and ?9.00 mV, respectively. The in vitro drug release from these alprazolam-loaded nanoparticles showed sustained drug release over a period of 24 h. In conclusion, these newly developed chitosan-egg albumin-PEG nanoparticles were found to be a promising vehicle for sustained release delivery of lipophilic drugs.