Tamarind seed polysaccharide-gellan mucoadhesive beads for controlled release of metformin HCl

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• 作者：Amit Kumar Nayak ; Dilipkumar Pal ; Kousik Santra
• 关键词：Tamarind seed polysaccharide ; Gellan gum ; Polymer-blend ; Mucoadhesion ; Controlled drug release ; Metformin HCl
• 刊名：Carbohydrate Polymers
• 出版年：15 March, 2014
• 年：2014
• 卷：103
• 期：Complete
• 页码：154-163
• 全文大小：2019 K

文摘

The paper describes the development, optimization and evaluation of tamarind seed polysaccharide (TSP)-blended gellan gum (GG) mucoadhesive beads containing metformin HCl through Ca²⁺-ion cross-linked ionic gelation for oral drug delivery. Effects of GG to TSP ratio and cross-linker (CaCl₂) concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 h (R_10h, %) of TSP-GG mucoadhesive beads containing metformin HCl were optimized by 32 factorial design. The optimized mucoadhesive beads (F-O) showed DEE of 95.73 卤 4.02%, R_10h of 61.22 卤 3.44% and mean diameter of 1.70 卤 0.24 mm.These beads were characterized by SEM and FTIR analyses. The in vitro drug release from these beads showed controlled-release (zero-order) pattern over a period of 10 h.The optimized TSP-GG mucoadhesive beads also exhibited pH-dependent swelling, good mucoadhesivity with biological mucosal membrane and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.