Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro-in vivo evaluations

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• 作者：Jadupati Malakar ; Prabir Kumar Datta ; Saikat Das Purakayastha ; Sanjay Dey ; Amit Kumar Nayak
• 关键词：Salbutamol sulfate ; Gastroretention ; Floating system
• 刊名：International Journal of Biological Macromolecules
• 出版年：March, 2014
• 年：2014
• 卷：64
• 期：Complete
• 页码：181-189
• 全文大小：2013 K

文摘

The present study deals with the development and evaluations of stomach-specific floating capsules containing salbutamol sulfate-loaded oil-entrapped alginate-based beads. Salbutamol sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10 h (R_10 h) from capsules was analyzed by 3² factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R_10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 卤 3.16% and R_10 h of 56.96 卤 2.92%. These capsules showed floatation over 6 h and sustained drug release over 10 h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.