Blends of jackfruit seed starch-pectin in the development of mucoadhesive beads containing metformin HCl

详细信息    查看全文

• 作者：Amit Kumar Nayak ; Dilipkumar Pal
• 关键词：Pectin ; Jackfruit seed starch ; Polymer-blend ; Mucoadhesion ; Ionotropic-gelation ; Drug release
• 刊名：International Journal of Biological Macromolecules
• 出版年：November, 2013
• 年：2013
• 卷：62
• 期：Complete
• 页码：137-145
• 全文大小：1749 K

文摘

In this work, calcium pectinate-jackfruit (Artocarpus heterophyllus Lam.) seed starch (JFSS) mucoadhesive beads containing metformin HCl were developed through ionotropic-gelation. Effects of pectin and JFSS amounts on drug encapsulation efficiency (DEE), and cumulative drug release after 10 h (R_10 h) were optimized using 3² factorial design. The optimized calcium pectinate-JFSS beads containing metformin HCl showed DEE of 94.11 卤 3.92%, R_10 h of 48.88 卤 2.02%, and mean diameter of 2.06 卤 0.20 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The pH of test mediums was found critical for swelling and mucoadhesion of these beads. The optimized calcium pectinate-JFSS beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.